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Thursday, November 16, 2017

      Workshop A
        Maximizing access to fertility services
      Eli Y. Adashi, MD, MS, MA, Alan S. Penzias, MD, Barbara Collura, MA

      Workshop B
      Individualization of ovarian stimulation protocols
      Raoul Orvieto, MD, Nigel E. Pereira, MD, Andrea Weghofer, MD, PhD, MS, MBA

      Workshop C
      Changing and exchanging genomes in human IVF
      Dietrich M. Egli, PhD, Shoukhrat Mitalipov, PhD, Michael Zuccaro, PhD

      Workshop D
      Maximizing IVF outcomes for poor prognosis patients
     Norbert Gleicher, MD, David H. Barad, MD, MS, Yan-Guang Wu, PhD    slides    cases

      Workshop E
      Social, medical and economic realities of egg donation     slides
     Vitaly A. Kushnir, MD, Kara Goldman, MD, Nigel Pereira, MD

     Workshop F
     The FMR1 gene in female infertility
     Lisa M Pastore, PhD, Johsua Johnson, PhD

Scientific Program

Friday, November 17, 2017

8:00-8:30 Morning Coffee | Exhibition Area

Opening Session

8:30-8:45 Welcome and Announcement of the “Young Investigator Award”
David F. Albertini, USA and Norbert Gleicher, USA
8:45-9:15 The “Breaking News” Lecture: Gene correction in human gametes and embryos for the prevention of heritable diseases?
Shoukhrat Mitalipov, USA    slides

Session 1: The Future of Assisted Reproduction I

Chairs: Norbert Gleicher, USA and David F. Albertini, USA

9:15-9:45 Tolerating uncertainty – The next medical revolution
Richard Martin Schwartzstein, USA    slides
9:45-10:15 The self-correcting embryo
David F. Albertini, USA
10:15-10:45 Imaging follicle maturation in 3 dimensions
Diana Laird, USA
10:45-11:15 Rejuvenation and expanding life spans by inducing epigenetic changes
Juan Carlos Izpisua Belmonte, USA
11:15-11:35 Coffee Break | Poster Viewing in the Exhibition Area

Session 2: Successful Reproduction is Tolerance Dependent

Chairs: Vitaly Kushnir, USA and David Barad, USA

11:35-11:55 Induction of tolerance pathways for establishment and maintenance of pregnancy
Norbert Gleicher, USA    slides
11:55-12:25 Does the importance of microchimerism for long-term tolerance of organ transplants potentially also apply to tolerance of the fetal semi-allograft?
William J. Burlingham, USA
12:25-12:55 Pre- and peri-implantation factors involved in inducing tolerance (ignorance) during mammalian gestation
Danny Schust, USA    slides
12:55-1:10 Get your lunch “to go”

Lunch Break Debate – Bring your lunch

Chair: Norbert Gleicher, USA

1:10-2:10 Preimplantation Genetic Screening in association with IVF is:
Useful in improving IVF outcomes
James A. Grifo, USA    slides
Does not improve IVF outcomes and may actually impair them
Raoul Orvieto, Israel    slides

Session 3: PARADIGM CHANGE I: Polycystic Ovary Syndrome (PCOS), a Multi-Etiological Epigenetic Syndrome?

Chairs: Milton Leong, Canada and Raoul Orvieto, Israel

2:10-2:40 Bilateral nodular adrenal hyperplasia, a possible mechanism for hyperandrogenism in young women with PCOS
Constantine A. Stratakis, USA
2:40-3:00 Ontogeny of the new hypo-androgenic PCOS phenotype
Norbert Gleicher, USA    slides
3:00-3:30 Translational insights into PCOS from animal models
Daniel Anthony Dumesic, USA    slides
3:30-4:00 Coffee Break | Poster Viewing in the Exhibition Area

Session 4: The Future of Assisted Reproduction II

Chairs: Juan Carlos Izpisua Belmonte, USA and James A. Grifo, USA

4:00-4:30 Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Shoukhrat Mitalipov, USA    slides
4:30-5:00 Editing the nuclear and mitochondrial human genome
Dietrich M. Egli, USA
5:00-5:30 Germline editing and how it was “unmade” in the U.S.
Eli Y. Adashi, USA    slides
5:30-6:00 The ovarian function of the FMR1 gene
Lisa Pastore, USA    slides
6:00-7:00 Welcome Reception | Exhibition Area

Saturday, November 18, 2017

8:00-8:30 Morning Coffee | Exhibition Area

Session 5: Quintessential Questions in Assisted Reproduction

Chairs: Eli Y. Adashi, USA and Aaron J.W. Hsueh, USA

8:30-9:00 3-D printed mouse ovaries producing healthy offspring
Teresa K. Woodruff, USA    slides
9:00-9:30 Ovarian follicle imaging and activation
Aaron J.W. Hsueh, USA    slides
9:30-10:00 Gamete reconstitution in vitro
Katsuhiko Hayashi, Japan
10:00-10:30 Should PGS be used in older women?
Nigel E. Pereira, USA
10:30-10:50 Coffee Break | Poster Viewing in the Exhibition Area

Session 6: PARADIGM CHANGE II: Preventing Rather Than Treating Female Infertility

Chairs: Neeta Singh, India and Kara Goldman, USA

10:50-11:20 The physiology of ovarian aging
David F. Albertini, USA
11:20-11:50 Can we prevent female infertility through proactive screening programs?
Vitaly A. Kushnir, USA    slides
11:50-12:20 How realistic an option is fertility preservation in preventing future infertility?
David H. Barad, USA    slides
12:20-12:50 Eggs and sperm from buccal smears?
Eli Y. Adashi, USA    slides
12:50-1:15 Get your lunch “to go”

Lunch Break Debate – Bring your lunch

Chair: David H. Barad, USA

1:15-2:30 How important is the implantation window?
Absolutely important
Carlos Simon, Spain    slides
Relatively unimportant
David F. Albertini, USA

Session 7: PARADIGM CHANGE III: Avoiding in IVF Practice “Fashions of the Moment”

Chairs: Carlos Simon, Spain and Vitaly A. Kushnir, USA

2:30-2:50 Does mild stimulation make any sense?
Raoul Orvieto, Israel    slides
2:50-3:10 Is there any reason for embryo banking but to artificially inflate outcomes?
Vitaly A. Kushnir, USA    slides
3:10-3:30 Are all-freeze cycles, followed by frozen-thawed embryo transfer cycles really improving IVF outcomes?
Andrea Weghofer, Austria    slides
3:30-3:50 Manual or automated embryology?
Norbert Gleicher, USA    slides
3:50-4:20 Coffee Break | Poster Viewing in the Exhibition Area

Session 8: PARADIGM CHANGE IV: Reading the Medical Literature with Appropriate Scepticism

Chairs: Andrea Weghofer, Austria and Raoul Orvieto, Israel

4:20-4:40 Minimal evidence required before introduction of treatments to routine clinical practice: Is there a responsibility for medical journals?
Nancy C. Chescheir, USA    slides
4:40-5:00 Advantages and risks of RCTs
David H. Barad, USA    slides
5:00-5:20 Why in IVF outcome reporting based on “intent to treat” is essential
Vitaly A. Kushnir, USA    slides
5:20-5:40 The journal editors’ responsibilities
David F. Albertini, USA

Sunday, November 19, 2017

8:30-9:00 Morning Coffee

Session 9: Ovarian Physiology

Chairs: David L. Keefe, USA and Zeev Shoham, Israel

9:00-9:30 How important is telomere attrition for female infertility?
David L. Keefe, USA    slides
9:30-10:00 Preserving female fertility during chemotherapy
Kara Goldman, USA
10:00-10:30 What is an old follicle?
Pasquale Patrizio, USA    slides
10:30-11:00 The importance of age-appropriate timing of ovulation induction
David H. Barad, USA    slides
11:00-11:30 Coffee Break

Session 10: Quick Updates on the “Most Interesting” Presentations at the 2017 ESHRE and ASRM Meetings and Still Unpublished Data

Chairs: Pasquale Patrizio, USA and Norbert Gleicher, USA

11:30-11:50 First results from ESHRE’S ESTEEM trial of PGS by polar body biopsy
David H. Barad, USA    slides
11:50-12:10 Bone marrow-derived stem cells to treat Asherman’s syndrome
Carlos Simon, Spain    slides
12:10-12:30 2014-2016 IVF outcomes with autologous oocytes in women ages 43-48, including the oldest so-far delivery in the world
Norbert Gleicher, USA    slides
12:30-1:00 Closing Lecture: New experimental insights into establishments of the ovarian reserve and their clinical implications
Humphrey Yao, USA    slides

Closing Remarks

Norbert Gleicher, USA